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As a first-time user, if you’re concerned about how you might react to CBD, the advice is simple—start low and slow. Aside from the possible side effects listed above, there is also the cannabinoid's potential interaction with prescription medication to consider. While it doesn’t interact directly with these medications, it does affect the enzymes responsible for breaking them down. There are a handful of documented side effects from continued consumption of CBD. Thankfully, all side effects not only appear mild, but dissipate quickly, in part due to the cannabinoid’s short half-life.